Usefulness of faecal calprotectin measurement in children with various types of inflammatory bowel disease.
Mediators Inflamm
; 2012: 608249, 2012.
Article
em En
| MEDLINE
| ID: mdl-22665952
ABSTRACT
INTRODUCTION:
The aim of the study was to assess the usefulness of the FC measurement in children with various types of IBD and relation to the disease activity. PATIENTS ANDMETHODS:
91 patients (49 boys 53.85% and 42 girls 46.15%, mean age 13.38 years, range 6-18 years) were included in the analysis. Patients were divided into the groups B1-24 children with CD, B2-16 patients with UC, and a group comprising 31 children with other types of colitis; the control group (K) comprised 20 healthy children. FC was assayed by ELISA method, using Phical test (Calpro).RESULTS:
The mean faecal calprotectin concentrations were higher in children with CD and UC as compared to healthy controls, patients with eosinophilic, lymphocytic, and nonspecific colitis. A positive correlation was observed between FC concentrations and the disease activity (the PCDAI scale, the Truelove-Witts Scale, and the endoscopic Rachmilewitz Index).CONCLUSION:
It seems that the FC concentrations can be a useful, safe, and noninvasive test in children suspected for IBD, since FC concentration is higher in children with CD and UC than in patients with other inflammatory diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Complexo Antígeno L1 Leucocitário
/
Fezes
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mediators Inflamm
Assunto da revista:
BIOQUIMICA
/
PATOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Polônia