The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury.
PPAR Res
; 2012: 802384, 2012.
Article
em En
| MEDLINE
| ID: mdl-22675337
ABSTRACT
Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
PPAR Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha