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Mechanisms of intracellular scaling.
Levy, Daniel L; Heald, Rebecca.
Afiliação
  • Levy DL; Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA. dlevy1@uwyo.edu
Annu Rev Cell Dev Biol ; 28: 113-35, 2012.
Article em En | MEDLINE | ID: mdl-22804576
ABSTRACT
Cell size varies widely among different organisms as well as within the same organism in different tissue types and during development, which places variable metabolic and functional demands on organelles and internal structures. A fundamental question is how essential subcellular components scale to accommodate cell size differences. Nuclear transport has emerged as a conserved means of scaling nuclear size. A meiotic spindle scaling factor has been identified as the microtubule-severing protein katanin, which is differentially regulated by phosphorylation in two different-sized frog species. Anaphase mechanisms and levels of chromatin compaction both act to coordinate cell size with spindle and chromosome dimensions to ensure accurate genome distribution during cell division. Scaling relationships and mechanisms for many membrane-bound compartments remain largely unknown and are complicated by their heterogeneity and dynamic nature. This review summarizes cell and organelle size relationships and the experimental approaches that have elucidated mechanisms of intracellular scaling.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamanho Celular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Annu Rev Cell Dev Biol Assunto da revista: BIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamanho Celular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Annu Rev Cell Dev Biol Assunto da revista: BIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos