Determining predictors of response to exenatide in type 2 diabetes.
J Am Pharm Assoc (2003)
; 52(4): 466-71, 2012.
Article
em En
| MEDLINE
| ID: mdl-22825226
ABSTRACT
OBJECTIVES:
To determine predictors of glycemic response to exenatide and to assess change in glycosylated hemoglobin (A1C) and whether a correlation exists between weight loss and glycemic response.DESIGN:
Retrospective observational cohort study.SETTING:
United States in 2009. PATIENTS 100 adult patients with type 2 diabetes prescribed exenatide. INTERVENTION Retrospective chart review of patients to collect demographic data, weight, serum creatinine, diabetes education, and concurrent diabetes medications. MAIN OUTCOMEMEASURES:
Patients were categorized as responders or nonresponders based on change in A1C. Responders had an A1C decrease of 0.5% or more and nonresponders had an A1C decrease of less than 0.5% from baseline to post-exenatide initiation. Demographic data for each cohort were analyzed.RESULTS:
100 patients met inclusion criteria (61 responders and 39 nonresponders). Responders had a mean A1C decrease of 1.57%, whereas nonresponders had a mean A1C increase of 0.23% (P < 0.001). Post hoc linear regression analysis revealed that baseline A1C was a predictor of response to exenatide (P < 0.001). Binary logistic regression analysis demonstrated that no other variables were predictors of response to exenatide (P > 0.05 for all). No correlation was found between weight loss and exenatide and glycemic response (P = 0.99).CONCLUSION:
Our data indicate that patients with a higher baseline A1C are more likely to have a glycemic response to exenatide than patients with a lower baseline A1C.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Peçonhas
/
Diabetes Mellitus Tipo 2
/
Hipoglicemiantes
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Am Pharm Assoc (2003)
Assunto da revista:
FARMACIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos