The continual presence of C3d but not IgG glomerular capillary deposition in stage I idiopathic membranous nephropathy in patients receiving corticosteroid treatment.
Diagn Pathol
; 7: 109, 2012 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-22909298
ABSTRACT
BACKGROUND:
Pathologic diagnosis of stage I idiopathic membranous nephropathy (MN-I) requires electron microscopy or immunohistochemistry that shows a glomerular capillary staining pattern of IgG and C3. However, it is not uncommon that renal biopsy did not obtain sufficient material for electron microscopy and that IgG and C3 staining in glomeruli largely lost at biopsy due to corticosteroid treatment. Since C3d is one of the final degradation products of C3 that is more stable in vivo, we determine if C3d staining could be used as a novel immunohistochemical marker for MN-I. METHODS ANDRESULTS:
74 MN-I patients with electron microscopy proven MN-I were examined by immunoperoxidase staining of C3d. Intensive C3d staining was present in glomerular capillary like the staining pattern of IgG and C3 in MN-I. Importantly, in 40 MN-I patients who underwent corticosteroid treatment at biopsy the intensity and glomerular capillary pattern of C3d staining remained largely intact while the staining for IgG had substantially reduced and the pattern of glomerular capillary staining became unrecognizable.CONCLUSIONS:
C3d glomerular capillary staining may be a novel marker for pathologic diagnosis of MN-I that is continuously present at biopsy in patient who has received corticosteroid treatment. VIRTUAL SLIDES The virtual slide(s) for this article can be found here http//www.diagnosticpathology.diagnomx.eu/vs/2120780075734479.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Capilares
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Glomerulonefrite Membranosa
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Complemento C3d
/
Corticosteroides
/
Glomérulos Renais
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
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Child
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Diagn Pathol
Assunto da revista:
PATOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China