X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues.
Anal Bioanal Chem
; 404(5): 1287-96, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22918568
ABSTRACT
We demonstrate that, with appropriate staining, high-resolution X-ray microscopy can image complicated tissue structures--cerebellum and liver--and resolve large or small amounts of Au nanoparticles in these tissues. Specifically, images of tumor tissue reveal high concentrations of accumulated Au nanoparticles. PEG (poly(ethylene glycol)) coating is quite effective in enhancing this accumulation and significantly modifies the mechanism of uptake by reticuloendothelial system (RES) organs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Tomografia Computadorizada por Raios X
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Nanopartículas
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Ouro
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Microscopia
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Neoplasias
Limite:
Animals
Idioma:
En
Revista:
Anal Bioanal Chem
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Taiwan