LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.
Biochem Soc Trans
; 40(5): 1074-9, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22988868
ABSTRACT
Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene are the most frequent genetic cause of PD (Parkinson's disease), and these mutations play important roles in sporadic PD. The LRRK2 protein contains GTPase and kinase domains and several protein-protein interaction domains. The kinase and GTPase activity of LRRK2 seem to be important in regulating LRRK2-dependent cellular signalling pathways. LRRK2's GTPase and kinase domains may reciprocally regulate each other to direct LRRK2's ultimate function. Although most LRRK2 investigations are centred on LRRK2's kinase activity, the present review focuses on the function of LRRK2's GTPase activity in LRRK2 physiology and pathophysiology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Proteínas Serina-Treonina Quinases
/
GTP Fosfo-Hidrolases
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos