Organocatalytic asymmetric addition of malonates to unsaturated 1,4-diketones.
Beilstein J Org Chem
; 8: 1452-7, 2012.
Article
em En
| MEDLINE
| ID: mdl-23019480
ABSTRACT
The organocatalytic Michael addition of malonates to symmetric unsaturated 1,4-diketones catalyzed by thiourea and squaramide derivatives with Cinchona alkaloids afforded the formation of a new C-C bond in high yields (up to 98%) and enantiomeric purities (up to 93%). The absolute configuration of the product was suggested from comparison of the experimental and calculated VCD spectra of the reaction product 3a.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estônia