Immunoglobulin kappa C predicts overall survival in node-negative breast cancer.
PLoS One
; 7(9): e44741, 2012.
Article
em En
| MEDLINE
| ID: mdl-23028600
ABSTRACT
BACKGROUND:
Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. MATERIAL ANDMETHODS:
IGKC expression was evaluated by immunostaining in a cohort of 335 node-negative breast cancer patients with a median follow-up of 152 months. The prognostic significance of IGKC for disease-free survival (DFS) and breast cancer-specific overall survival (OS) was evaluated with Kaplan-Meier survival analysis as well as univariate and multivariate Cox analysis adjusted for age at diagnosis, pT stage, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 and human epidermal growth factor receptor 2 (HER-2) status.RESULTS:
160 patients (47.7%) showed strong expression of IGKC. Univariate analysis showed that IGKC was significantly associated with DFS (Pâ=â0.017, hazard ratio [HR]â=â0.570, 95% confidence interval [CI]â=â0.360-0.903) and OS (Pâ=â0.011, HRâ=â0.438, 95% CIâ=â0.233-0.822) in the entire cohort. The significance of IGKC was especially strong in ER negative and in luminal B carcinomas. In multivariate analysis IGKC retained its significance independent of established clinical factors for DFS (Pâ=â0.004, HRâ=â0.504, 95% CIâ=â0.315-0.804) as well as for OS (Pâ=â0.002, HRâ=â0.371, 95% CIâ=â0.196-0.705).CONCLUSION:
Expression of IGKC has an independent protective impact on DFS and OS in node-negative breast cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Cadeias kappa de Imunoglobulina
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Alemanha