Splice variants of the Alzheimer's disease beta-secretase, BACE1.
Neurogenetics
; 14(1): 1-9, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23142975
ABSTRACT
Cleavage of the amyloid precursor protein by enzymes commonly referred to as ß- and γ-secretase constitute an important process in the pathogenesis of Alzheimer's disease (AD). The regulation of this process is therefore an important subject of investigation. Numerous sources of endogenous regulation have been identified, and one of these is the relative abundance and regulation of splice variants of the ß-secretase, BACE1 (ß-site amyloid precursor protein cleaving enzyme 1). In this review, we will briefly discuss the main characteristics of BACE1, review the different variants of this enzyme that have been identified to date, and highlight their possible implication in AD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Splicing de RNA
/
Ácido Aspártico Endopeptidases
/
Secretases da Proteína Precursora do Amiloide
/
Doença de Alzheimer
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neurogenetics
Assunto da revista:
GENETICA
/
NEUROLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Austrália