Thymic epithelium tolerizes for histocompatibility antigens.
Science
; 247(4949 Pt 1): 1471-4, 1990 Mar 23.
Article
em En
| MEDLINE
| ID: mdl-2321009
ABSTRACT
The role of thymic epithelium in the establishment of tissue tolerance was analyzed with a murine chimeric system. All T cells differentiated from birth onward in a thymus comprising allogeneic epithelium and syngeneic hematopoietic cells. Embryonic thymic rudiments that contained no hematopoietic cells from C3H (H-2k) donors were grafted to newborn athymic (nude) BALB/c (H-2d) mice. Chimeras that had normal T cell numbers and function rejected third-party skin grafts, but permanently accepted grafts syngeneic to the thymic epithelium. In vitro functional assays did not always correlate with the state of tolerance in vivo. Thus, pure thymic epithelium induces tolerance to histocompatibility antigens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Sobrevivência de Enxerto
/
Antígenos de Histocompatibilidade
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1990
Tipo de documento:
Article