The effect of taurine on age-related immune decline in mice: the effect of taurine on T cell and B cell proliferative response under costimulation with ionomycin and phorbol myristate acetate.
Mech Ageing Dev
; 52(2-3): 125-39, 1990 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-2325429
ABSTRACT
Proliferative responses to the costimulation with phorbol-12-myristate-13-acetate (PMA) and suboptimal doses of ionomycin in the purified T and B cells from old mice were lower than those from young mice. The degree of the age-related decline was more significant in T cells than in B cells. Taurine, a sulfur containing amino acid, augmented the proliferative responses of T cells from both young and old mice. The augmentation of the proliferative response by taurine was more marked in old T cells than in young ones. The concentration of intracellular free calcium ion ([Ca2+]i) was significantly lower in the old T cells under the stimulation with PMA and ionomycin than that in the young ones. In the presence of taurine, the concentration of [Ca2+]i in the old T cell significantly increased under the stimulation. The results indicate that taurine improved the proliferative response of old T cells by the restoration of the increment of the concentration of [Ca2+]i under the stimulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taurina
/
Envelhecimento
/
Acetato de Tetradecanoilforbol
/
Ativação Linfocitária
/
Ionomicina
Limite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão