Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes.
Am J Clin Nutr
; 97(2): 255-60, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23283507
ABSTRACT
BACKGROUND:
Angiopoietin-like protein 4 (ANGPTL4) has been identified as an inhibitor of lipoprotein lipase. Preliminary data suggest that plasma nonesterified fatty acids (NEFAs) raise plasma ANGPTL4 concentrations in humans.OBJECTIVE:
The objective was to assess plasma ANGPTL4 concentrations after various nutritional interventions that increase NEFA concentrations in healthy subjects and in patients with type 2 diabetes mellitus.DESIGN:
We studied 4 groups, both at baseline and after 3 d of either fasting (n = 22 healthy men), a very-low-calorie diet (VLCD; n = 10 healthy men and n = 10 patients with diabetes), or a high-fat, high-energy diet (HFED; n = 15 healthy men). Plasma ANGPTL4, NEFA, and triglyceride concentrations were measured.RESULTS:
In healthy men, a VLCD increased ANGPTL4 from 13.2 (IQR 8.1-24.2) at baseline to 18.2 (16.7-33.4) ng/mL (P < 0.05), fasting increased ANGPTL4 from 10.6 (7.6-17.6) to 28.0 (23.1-35.0) ng/mL (P < 0.05), and an HFED increased ANGPTL4 from 13.9 (8.2-22.0) to 17.2 (11.2-23.6) ng/mL (P < 0.05). In men with diabetes, a VLCD also increased ANGPTL4, from 10.9 ± 2.4 to 19.2 ± 3.2 ng/mL (P < 0.05). All interventions significantly increased plasma NEFAs in both healthy men and patients with diabetes. The change in ANGPTL4 positively correlated with the change in NEFA concentrations (ß = 0.048, P < 0.001) and negatively correlated with the change in plasma triglycerides (ß = -0.051, P = 0.01).CONCLUSIONS:
Three days of either fasting, a VLCD, or an HFED increased plasma ANGPTL4 concentrations in healthy men, concomitantly with increased plasma NEFA concentrations. Similarly, a VLCD in patients with diabetes increased ANGPTL4 concentrations, concomitantly with increased NEFA concentrations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ingestão de Energia
/
Regulação para Cima
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Restrição Calórica
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Angiopoietinas
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Diabetes Mellitus Tipo 2
/
Ácidos Graxos não Esterificados
Limite:
Adult
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Holanda