Role of matrix ß-1,3 glucan in antifungal resistance of non-albicans Candida biofilms.
Antimicrob Agents Chemother
; 57(4): 1918-20, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-23318790
ABSTRACT
Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to ß-1,3 glucan. Here, we show this is important for other Candida spp. We identified ß-1,3 glucan in the matrix, found that the matrix sequesters antifungal drug, and enhanced antifungal susceptibility with matrix ß-1,3 glucan hydrolysis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Biofilmes
/
Farmacorresistência Fúngica
/
Beta-Glucanas
/
Antifúngicos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos