Dry eye as a mucosal autoimmune disease.
Int Rev Immunol
; 32(1): 19-41, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-23360156
ABSTRACT
Dry eye is a common ocular surface inflammatory disease that significantly affects quality of life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular surface homeostasis, facilitating chronic inflammation and tissue damage. Accordingly, the most effective treatments to date are geared towards reducing inflammation and restoring normal tear film. The pathogenic role of CD4+ T cells is well known, and the field is rapidly realizing the complexity of other innate and adaptive immune factors involved in the development and progression of disease. The data support the hypothesis that dry eye is a localized autoimmune disease originating from an imbalance in the protective immunoregulatory and proinflammatory pathways of the ocular surface.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Síndromes do Olho Seco
/
Linfócitos T CD4-Positivos
/
Aparelho Lacrimal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article