Association of microRNA-181c expression with the progression and prognosis of human gastric carcinoma.
Hepatogastroenterology
; 60(125): 961-4, 2013.
Article
em En
| MEDLINE
| ID: mdl-23425811
ABSTRACT
BACKGROUND/AIMS:
The relationship of miR-181c, a potential tumor regulatory factor, with gastric cancer is not well studied. We have investigated this relationship in our study.METHODOLOGY:
Paraffin-embedded tissue specimens from 103 gastric cancer patients were subjected to total RNA extraction. Reverse transcription real-time fluorescence quantitative PCR was used to detect miR-181c expression. Its relative expression was correlated with the patients' clinicopathological features. Also, the 5-year survival rate and median survival time were correlated with the miR-181c expression level.RESULTS:
miR-181c expression was significantly and directly correlated with the degree of tumor differentiation, invasive depth and clinical stage. Moreover, lymph node metastasis was significantly related with higher miR-181c expression. However, miR-181c expression was not significantly correlated with gender, age, tumor location and distant metastasis. The 5-year overall survival rate and median survival time were significantly greater in patients with low expression of miR-181c.CONCLUSIONS:
miR-181c expression level was significantly related to several clinicopathological features of gastric cancer; therefore, miR-181c probably plays a role in its development and progression. This relationship needs to be studied in detail, so that the potential use of miR-181c as a marker for gastric cancer and therapeutic target can be explored.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
MicroRNAs
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Ano de publicação:
2013
Tipo de documento:
Article