N-[4-(9-Chloro-quino[3,2-b]benzo[1,4]thia-zin-6-yl)but-yl]acetamide.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 12): o3324-5, 2012 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-23476166
ABSTRACT
In the title mol-ecule, C21H20ClN3OS, the tetra-cyclic system is close to planar [r.m.s. deviation = 0.110â
(4)â
Å]. The dihedral angle between the quinoline ring system and the benzene ring is 178.3â
(1)° and the angle between two (S-C=C-N) halves of the thia-zine ring is 173.4â
(1)°. In the crystal, mol-ecules are arranged via π-π inter-actions [centroid-centroid distances = 3.603â
(2)-3.739â
(2)â
Å] into slipped stacks extending along [010]. Inter-molecular N-Hâ¯O hydrogen bonds link the amide groups of neighbouring mol-ecules along the stack, generating a C(4) motif. The title compound shows promising anti-proliferative and anti-cancer activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Acta Crystallogr Sect E Struct Rep Online
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Polônia