Toll-like receptor-expressing cells for antiallergy compound screening.
Expert Opin Drug Discov
; 3(6): 629-41, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-23506145
ABSTRACT
BACKGROUND:
Regulation of type 2 helper T cell (TH2) polarization by toll-like receptors (TLRs) has triggered great interest in new antiallergic therapeutics. In addition to being involved in the regulation of co-stimulation by antigen-presenting cells, they are expressed on other immune and non-immune cells.OBJECTIVE:
To review the expression and function of TLRs on these cells and their potential to regulate TH2-associated responses.METHODS:
We focused on human cells that can be used for in vitro testing of TLR agonists. RESULTS/CONCLUSION:
Many cells involved in the allergic reaction have the capacity to respond to TLR agonists. Therefore, one needs to be cautious in extrapolating the antiallergic effect of a TLR agonist from the response analyzed in one cell type. Therefore, it is suggested that several cell types should be studied.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Expert Opin Drug Discov
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França