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Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model.
Yokobori, Shoji; Bullock, Ross; Gajavelli, Shyam; Burks, Stephen; Mondello, Stefania; Mo, Jixiang; Wang, Kevin K W; Hayes, Ronald L; Bramlett, Helen; Dietrich, Dalton.
Afiliação
  • Yokobori S; Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA. syokobori@med.miami.edu
Acta Neurochir Suppl ; 118: 77-81, 2013.
Article em En | MEDLINE | ID: mdl-23564108
ABSTRACT
Post-traumatic hypothermia has been effective for traumatic brain injury in the laboratory setting. However, hypothermia has not shown efficacy in clinical trials. With the results of a recent clinical trial, we hypothesized that hypothermia might reduce neuronal damage in acute subdural hematoma (ASDH) by blunting the effects of reperfusion injury. Twenty rats were induced with ASDH and placed into one of four groups. The normothermia group was maintained at 37 °C throughout. In the early hypothermia group, brain temperature was reduced to 33 °C 30 min prior to craniotomy. In the late hypothermia group, brain temperature was lowered to 33 °C 30 min after decompression. The sham group had no ASDH and underwent only craniotomy with normothermia. For estimation of glial and neuronal cell damage, we analyzed serum and microdialysate (using a 100kD probe) concentrations of glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl--terminal hydrolase -L1 (UCH-L1). Hypothermia induced early significantly reduced the concentration of MD UCH-L1. In conclusion, hypothermia induced early may reduce neuronal cell damage in the reperfusion injury, which was induced after ASDH removal. MD UCH-L1 seems like a good -candidate for a sensitive microdialysate biomarker for -neuronal injury and outcome.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hematoma Subdural / Hipotermia Induzida / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Neurochir Suppl Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hematoma Subdural / Hipotermia Induzida / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Neurochir Suppl Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos