Mechanical control of cell flow in multicellular spheroids.
Phys Rev Lett
; 110(13): 138103, 2013 Mar 29.
Article
em En
| MEDLINE
| ID: mdl-23581378
ABSTRACT
Collective cell motion is observed in a wide range of biological processes. In tumors, physiological gradients of nutrients, growth factors, or even oxygen give rise to gradients of proliferation. We show using fluorescently labeled particles that these gradients drive a velocity field resulting in a cellular flow in multicellular spheroids. Under mechanical stress, the cellular flow is drastically reduced. We describe the results with a hydrodynamic model that considers only convection of the particles by the cellular flow.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Esferoides Celulares
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Phys Rev Lett
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França