Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients.
Neurobiol Aging
; 11(3): 169-73, 1990.
Article
em En
| MEDLINE
| ID: mdl-2362649
ABSTRACT
It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Córtex Cerebral
/
Doença de Alzheimer
Limite:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Holanda