A murine model of stent implantation in the carotid artery for the study of restenosis.
J Vis Exp
; (75): e50233, 2013 May 14.
Article
em En
| MEDLINE
| ID: mdl-23711999
ABSTRACT
Despite the considerable progress made in the stent development in the last decades, cardiovascular diseases remain the main cause of death in western countries. Beside the benefits offered by the development of different drug-eluting stents, the coronary revascularization bears also the life-threatening risks of in-stent thrombosis and restenosis. Research on new therapeutic strategies is impaired by the lack of appropriate methods to study stent implantation and restenosis processes. Here, we describe a rapid and accessible procedure of stent implantation in mouse carotid artery, which offers the possibility to study in a convenient way the molecular mechanisms of vessel remodeling and the effects of different drug coatings.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias Carótidas
/
Stents
/
Reestenose Coronária
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
En
Revista:
J Vis Exp
Ano de publicação:
2013
Tipo de documento:
Article