Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels.
J Am Geriatr Soc
; 61(6): 957-962, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23730808
ABSTRACT
OBJECTIVES:
To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo-controlled 24-week study.DESIGN:
Randomized, double-blind, placebo-controlled.SETTING:
Odense, Denmark.PARTICIPANTS:
Men aged 60 to 78, with bioavailable testosterone levels of less than 7.3 nmol/L and a waist circumference greater than 94 cm were randomized to testosterone (50-100 mg/d, n = 22) placebo (n = 23) or strength training (n = 23) for 24 weeks. The strength training group was randomized to addition of testosterone or placebo after 12 weeks. Subjects performed supervised strength training (2-3 sets with 6- to 10-repetition maximum loads, 3 times per week). MEASUREMENTS Testosterone levels, maximal voluntary contraction and rate of force development, and LBM were obtained at 0 and at Weeks 12 and 24 of the intervention.RESULTS:
No changes in any variables were recorded with placebo. In the strength training group, maximal voluntary contraction increased 8% after 12 weeks (P = .005). During the following 12 weeks of strength training rate of force development increased by 10% (P = .04) and maximal voluntary contraction further increased (P < .001). Mechanical muscle function was unchanged in men receiving only testosterone for 24 weeks. LBM increased only in men receiving testosterone (P = .004).CONCLUSION:
Strength training in aging men with low-normal testosterone levels may improve mechanical muscle function, but this effect occurs without a significant increase in LBM. Clinically, only the combination of testosterone therapy and strength training resulted in an increase in mechanical muscle function and LBM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Magreza
/
Envelhecimento
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Músculo Esquelético
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Força Muscular
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Treinamento Resistido
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Hipogonadismo
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Am Geriatr Soc
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Dinamarca