A theoretical investigation of photoacoustic contrast agents.
J Acoust Soc Am
; 133(6): 3853-62, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23742340
ABSTRACT
Photoacoustic imaging offers significant potential as a biomedical imaging modality. For some applications, however, there is a need for contrast enhancement. In this paper, a theoretical comparison is presented of the efficacy of three different designs for photoacoustic contrast agents (PACAs), specifically, a droplet of dye, a bubble filled with gas coated by a dye loaded shell, and a droplet of volatile dye. For each case, the governing equations describing the dynamics of a single PACA in a homogenous incompressible fluid are derived. The coupled sets of equations describing the bubble oscillation and resulting radiated pressure, the photo-acoustic energy equation, and the equation of state are then solved numerically. The numerical results predict a stronger radiated acoustic signal for the same optical source energy density in the case of the volatile dye droplet by a factor of up to two orders of magnitude compared with the other two types of agent.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diagnóstico por Imagem
/
Aumento da Imagem
/
Meios de Contraste
/
Microbolhas
/
Corantes
/
Técnicas Fotoacústicas
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Acoust Soc Am
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido