Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome.
Clin Exp Ophthalmol
; 42(2): 132-8, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-23777553
ABSTRACT
BACKGROUND:
The study aims to investigate whether retinal nerve fibre layer (RNFL) abnormalities can be detected in patients with obstructive sleep apnoea/hypopnoea syndrome with normally appearing optic disc.DESIGN:
This is an observational case-control study.PARTICIPANTS:
One hundred and eight consecutive patients with moderate or severe obstructive sleep apnoea/hypopnoea syndrome (OSAHS) as determined by overnight polysomnography and normal looking discs and 108 age-matched healthy controls were included in the study.METHODS:
All patients underwent RNFL examinations by optical coherence tomography using fast retinal nerve fibre layer thickness scan. MAIN OUTCOMEMEASURES:
The main outcome measure was RNFL thickness.RESULTS:
Multivariate regression analysis results showed that the RNFL was thinner for a patient with OSAHS than that of a normal control in the average by 4.20 µm (P < 0.003), in the superior quadrant by 4.83 µm (P = 0.028) and in the inferior quadrant by 5.19 µm (P = 0.016). RNFL thickness did not correlate with the severity of the disease.CONCLUSIONS:
RNFL thinning was detected in normal-looking discs of patients with advanced OSAHS, but the extent of this thinning did not correlate with the severity of the disease. Longitudinal follow-up is needed to clarify whether RNFL thinning in OSAHS patients with normal clinically appearing optic nerves will eventually lead to glaucoma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disco Óptico
/
Células Ganglionares da Retina
/
Doenças do Nervo Óptico
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Apneia Obstrutiva do Sono
/
Tomografia de Coerência Óptica
/
Fibras Nervosas
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Exp Ophthalmol
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Israel