Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling.
Mol Cell Proteomics
; 12(12): 3498-508, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23788531
ABSTRACT
The plasma membrane serves as a dynamic interface that relays information received at the cell surface into the cell. Lipid second messengers coordinate signaling on this platform by recruiting and activating kinases and phosphatases. Specifically, diacylglycerol and phosphatidylinositol 3,4,5-trisphosphate activate protein kinase C and Akt, respectively, which then phosphorylate target proteins to transduce downstream signaling. This review addresses how the spatiotemporal dynamics of protein kinase C and Akt signaling can be monitored using genetically encoded reporters and provides information on how the coordination of signaling at protein scaffolds or membrane microdomains affords fidelity and specificity in phosphorylation events.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
/
Sistemas do Segundo Mensageiro
/
Processamento de Proteína Pós-Traducional
/
Fosfatos de Fosfatidilinositol
/
Microdomínios da Membrana
/
Diglicerídeos
/
Proteínas Proto-Oncogênicas c-akt
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Cell Proteomics
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2013
Tipo de documento:
Article