Evaluation of dihydroisocoumarins produced by the endophytic fungus Arthrinium state of Apiospora montagnei against Schistosoma mansoni.
Nat Prod Res
; 27(23): 2240-3, 2013.
Article
em En
| MEDLINE
| ID: mdl-23805902
ABSTRACT
Fractionation of extracts from the fermentation broth of the endophytic fungus Arthrinium state of Apiospora montagnei resulted in the isolation of the major secondary metabolites, R-(-)-mellein (1) and cis-(3R,4R)-4-hydroxymellein (2). The chemical structures of compounds were determined by spectroscopic analyses. The isolated compounds were tested in vitro to determine their activity against Schistosoma mansoni adult worms. Compounds 1 and 2 caused death of 100% of parasites at 200 and 50 µg mL(-1), respectively. Ultrastructural analysis suggested that the tegument can be a target of compound 1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Schistosoma mansoni
/
Isocumarinas
Limite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2013
Tipo de documento:
Article