Cyclic lipodepsipeptides: a new class of antibacterial agents in the battle against resistant bacteria.
Future Med Chem
; 5(11): 1311-30, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23859209
ABSTRACT
In order to provide effective treatment options for infections caused by multidrug-resistant bacteria, innovative antibiotics are necessary, preferably with novel modes of action and/or belonging to novel classes of drugs. Naturally occurring cyclic lipodepsipeptides, which contain one or more ester bonds along with the amide bonds, have emerged as promising candidates for the development of new antibiotics. Some of these natural products are either already marketed or in advanced stages of clinical development. However, despite the progress in the development of new antibacterial agents, it is inevitable that resistant strains of bacteria will emerge in response to the widespread use of a particular antibiotic and limit its lifetime. Therefore, development of new antibiotics remains our most efficient way to counteract bacterial resistance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Farmacorresistência Bacteriana
/
Depsipeptídeos
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Future Med Chem
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos