Turning theory into practice: the development of modern transdermal drug delivery systems and future trends.
Skin Pharmacol Physiol
; 26(4-6): 331-42, 2013.
Article
em En
| MEDLINE
| ID: mdl-23921120
ABSTRACT
Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others in the 1960s helped to explain the processes involved in passive percutaneous absorption and led to the development of mathematical models to describe transdermal drug delivery. The intervening years have seen these theories turned to practice and a significant number of transdermal systems are now available including some that employ active drug delivery. This review briefly discusses the evolution of transdermal therapeutic systems over the years and the potential of newer transdermal technologies to deliver hydrophilic drugs and macromolecules through the skin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Absorção Cutânea
/
Sistemas de Liberação de Medicamentos
/
Modelos Teóricos
Limite:
Humans
Idioma:
En
Revista:
Skin Pharmacol Physiol
Assunto da revista:
DERMATOLOGIA
/
FARMACOLOGIA
/
FISIOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos