Bilateral areolar leiomyomas in a patient undergoing BRAF inhibition therapy for melanoma.
J Cutan Pathol
; 40(10): 884-6, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23924408
ABSTRACT
BRAF inhibition therapy, used to treat melanomas with BRAF mutations, is associated with both neoplastic and non-neoplastic cutaneous side effects including squamous cell carcinomas, warty dyskeratomas, verrucous keratoses, photosensitivity and widespread eruptions that present histopathologically as acantholytic dyskeratosis. We report a case of a patient undergoing BRAF inhibition therapy for disseminated melanoma with a V600E mutation who developed bilateral areolar leiomyomas, one of which was biopsied and the other of which resolved after discontinuation of vemurafenib therapy. To our knowledge, this is the first reported case of a mesenchymal neoplasm developing in association with BRAF inhibition therapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Segunda Neoplasia Primária
/
Proteínas Proto-Oncogênicas B-raf
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Indóis
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Leiomioma
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Melanoma
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos