Nanoemulsions for delivery of flavonoids: formulation and in vitro release of rutin as model drug.
Pharm Dev Technol
; 19(6): 677-80, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-23930932
ABSTRACT
The aim of the present study is to design and characterize a rutin-loaded nanoemulsion (RT-NE) and determine the release profile of the drug in vitro. RT-NE was prepared by a high pressure homogenization technique. The obtained droplets were analyzed by optical microscopy and were shown to be of spherical shape. By dynamic light scattering, characterization of RT-NE showed an average diameter of 127 nm, polydispersity index of 0.168 and zeta potential values near neutrality (-3.49 mV). Encapsulation efficiency was of â¼82% (82.3 ± 1.62%). Drug release was characterized by an initial burst which decreased over the time, showing a sustained release profile. After 24 h, rutin released from NE reached nearly 65%. The developed system proved to be stable and suitable to encapsulating poorly water-soluble drugs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Emulsões
/
Nanopartículas
Idioma:
En
Revista:
Pharm Dev Technol
Assunto da revista:
FARMACIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Portugal