One calcitriol dose transiently increases Helios+ FoxP3+ T cells and ameliorates autoimmune demyelinating disease.
J Neuroimmunol
; 263(1-2): 64-74, 2013 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-23968560
ABSTRACT
Multiple sclerosis (MS) is an incurable inflammatory demyelinating disease. We investigated one calcitriol dose plus vitamin D3 (calcitriol/+D) as a demyelinating disease treatment in experimental autoimmune encephalomyelitis (EAE). Evidence that calcitriol-vitamin D receptor pathway deficits may promote MS, and data showing calcitriol enhancement of autoimmune T cell apoptosis provided the rationale. Whereas vitamin D3 alone was ineffective, calcitriol/+D transiently increased central nervous system (CNS) Helios(+)FoxP3(+) T cells and sustainably decreased CNS T cells, pathology, and neurological deficits in mice with EAE. Calcitriol/+D, which was more effective than methylprednisolone, has potential for reversing inflammatory demyelinating disease safely and cost-effectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Calcitriol
/
Regulação para Cima
/
Subpopulações de Linfócitos T
/
Proteínas de Ligação a DNA
/
Encefalomielite Autoimune Experimental
/
Fatores de Transcrição Forkhead
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos