Low-dose estrogen and drospirenone combination: effects on metabolism and endothelial function in postmenopausal women with metabolic syndrome.
Clin Exp Obstet Gynecol
; 40(2): 233-5, 2013.
Article
em En
| MEDLINE
| ID: mdl-23971246
ABSTRACT
PURPOSE:
Metabolic syndrome and endothelial dysfunction play a relevant role in the cardiovascular risk in post-menopause. The aim of the study was to assess the effects of a low-dose hemihydrate estradiol and drospirenone combination on cardiovascular risk parameters in postmenopausal women with metabolic syndrome. MATERIALS ANDMETHODS:
Twenty-eight healthy women (group A) and 28 women with metabolic syndrome (group B) were treated with hemihydrate estradiol one mg + drospirenone two mg. At recruitment and after six months, clinical and laboratory parameters of metabolic syndrome were evaluated. Endothelial function was assessed measuring the flow-mediated dilatation of the brachial artery and the intima-media thickness of the common carotid artery.RESULTS:
After six months an overall improvement of metabolism was observed in both groups reaching statistical significance for triglycerides, total cholesterolemia, and systolic pressure in group B. A trend to lower baseline flow-mediated dilatation was also found in group B.CONCLUSIONS:
Drospirenone improves cardiovascular risk factors and does not impair endothelial function in menopausal women with metabolic syndrome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Pós-Menopausa
/
Síndrome Metabólica
/
Estrogênios
/
Androstenos
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Exp Obstet Gynecol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália