[Pathogenetic significance of interstitial fibrosis in development myocardial dysfunction and chronic heart failure in elderly patients with arterial hypertension].

ABSTRACT

To estimate the pathogenetic significance of interstitial fibrosis in development myocardial dysfunction in elderly patients with arterial hypertension the complex investigation of 84 patients (76 women and 8 men), suffering from arterial hypertension (AH) II stage and practically healthy 22 persons of advanced age was spent. It is established, that expressiveness of myocardial fibrosis in the elderly patients with AH, confirmed by an increase of volume fraction of interstitial collagen was accompanied by authentic change of serous level markers of its exchange decrease in concentration of the matrix metalloproteinasum-1 predecessor and increase its inhibitor. Progressing of myocardial dysfunction from diastolic variant to sistolo-diastolic one is interfaced to maintenance increase of extracellular matrix and its negative changes of serous markers, decrease of index collagen degradation, tolerance to physical activity, development forecasting adverse variants of heart remodelling