Choosing an animal model for the study of Huntington's disease.
Nat Rev Neurosci
; 14(10): 708-21, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-24052178
ABSTRACT
Since the identification of the causative gene in Huntington's disease (HD), a number of animal models of this disorder have been developed. A frequently asked question is which of these models most closely recapitulates the human disease? In this Review, we provide an overview of the currently available animal models of HD in the context of the clinical features of the disease. In doing so, we highlight their strengths and limitations for modelling specific symptoms of the disease. This should highlight the animal model that is best suited to address a particular question of interest and, ultimately, to expedite the discovery of treatments that will prevent or slow the progression of HD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
/
Modelos Animais de Doenças
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Singapura