Mechanisms controlling theophylline release from ethanol-resistant coated pellets.
Pharm Res
; 31(3): 731-41, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24072265
ABSTRACT
PURPOSE:
To elucidate the mass transport mechanisms controlling drug release from recently proposed, ethanol-resistant, polymeric film coatings.METHODS:
Theophylline matrix pellets were coated with ethylcellulose guar gum blends. Drug release from single pellets and ensembles of pellets was measured in various release media. Changes in the systems' morphology, composition and mechanical properties were monitored using SEM, gravimetrical analysis and a texture analyzer. Based on the obtained experimental results a mechanistically realistic mathematical model was identified and used to quantitatively predict drug release from coated pellets in ethanol-free and ethanol-containing bulk fluids.RESULTS:
Drug diffusion though the intact polymeric film coatings is likely to be the dominant mass transport mechanism in the investigated systems, irrespective of the ethanol content in the surrounding environment. An appropriate solution of Fick's law could be used to quantitatively predict theophylline release from pellets coated with different ethylcelluloseguar gum blends at different coating levels. Importantly, independent experiments confirmed the theoretical predictions.CONCLUSIONS:
In silico simulations can help facilitating the optimization of the novel ethanol-resistant polymeric film coatings, avoiding time-consuming and cost-intensive series of trial-and-error experiments. The presence/absence of ethanol does not affect the underlying drug release mechanisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Teofilina
/
Broncodilatadores
/
Portadores de Fármacos
/
Celulose
/
Etanol
/
Gomas Vegetais
/
Galactanos
/
Mananas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Pharm Res
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
França