Nutritional potential of metabolic remodelling of white adipose tissue.
Curr Opin Clin Nutr Metab Care
; 16(6): 650-6, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24100671
ABSTRACT
PURPOSE OF REVIEW Recent findings in animals suggest that diet-related factors can programme adipose tissue features in early life and remodel white adipose tissue (WAT) towards a brown adipose tissue (BAT)-like phenotype in adulthood, while impacting on body fat content and susceptibility to obesity. The purpose of this review is to address the significance of these results and their applicability in humans. RECENT FINDINGS:
Nutritional conditions in the perinatal period influence sympathetic innervation to WAT and WAT cellularity in rodents. Leptin intake during the suckling period prevents obesity and other metabolic alterations in later life in rats through mechanisms that include increased sensitivity of adipose tissues to leptin. Recent data support the thermogenic functionality of inducible brown-like cells in rodent WAT and functional thermogenic beige adipogenesis from human progenitor cells. Diet-related factors and exercise can promote BAT activation and/or WAT-to-BAT remodelling (WAT browning) in animals.SUMMARY:
Animal studies suggest that adipose tissue health and whole body adiposity might be influenced by early life nutrition and lifestyle factors in adulthood impacting energy metabolism in adipose tissues. For this knowledge to be translated to humans, biomarkers allowing early detection of the programming status of the individual and technologies allowing measuring of the thermogenic activity of adipose tissue depots in vivo are required.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estado Nutricional
/
Tecido Adiposo Branco
Tipo de estudo:
Screening_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Clin Nutr Metab Care
Assunto da revista:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Espanha