#, sieve number; %, percentage; 23 full factorial design; API, active pharmaceutical ingredient; BCS, biopharmaceutical classification system; BGMT, bilayered gastric mucoadhesive tablets; Bilayered gastric mucoadhesive tablets; CR layer, control release layer; G, grams; HCl, hydrochloric acid; Lamotrigine; MA layer, mucoadhesive layer; MDT, mean dissolution time; Methacrylic polymers; Mg, milligrams; Modified basket dissolution model; USP, United States pharmacopoeia; UV, ultra violet; Unidirectional drug release; Zero order release; cms, centimetres; f1, difference factor; f2, similarity factor; h, hours; mL, millilitre; min, minute; mm, millimetre; n, release exponent (power law Korsmeyer Peppas equation); nm, nanometre; r2, correlation coefficient; rpm, revolution per minute; sec, seconds; °C, degrees centigrade; ≈, approximately equivalent to