DFT for exploring the antioxidant potential of homogentisic and orsellinic acids.
Pak J Pharm Sci
; 26(6): 1209-14, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24191328
ABSTRACT
In recent years, much attention has been focused on the antioxidant potential of different phenolic acids. But still no theoretical investigation is reported on the antioxidant potential of Homogentisic and Orsellinic acids. In this study, computational investigation based on the density functional theory (DFT) has been carried out to understand the antioxidant potential of Homogentisic and Orsellinic acids. The bond dissociation enthalpy (BDE) of O-H, spin densities and electronic properties such as dipole moment, ionization potential, electron affinity, HOMO and LUMO energies, electronegativity, electrophilic index, energy gap, softness and hardness have been calculated. These properties show that both phenolic acids are good antioxidants. Comparison of BDE of Homogentisic and Orsellinic acids with many other phenolic acids also indicate the good antioxidant potential of these compounds. Homogentisic acid has very high antioxidant potential due to the presence of semiquinone structure. This study will be helpful for the better utilization of these compounds in pharmaceutical and food industry.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resorcinóis
/
Ácido Homogentísico
/
Antioxidantes
Idioma:
En
Revista:
Pak J Pharm Sci
Assunto da revista:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Paquistão