Pharmacodynamics of midodrine, an antihypotensive agent.
Clin Pharmacol Ther
; 39(5): 586-91, 1986 May.
Article
em En
| MEDLINE
| ID: mdl-2421958
ABSTRACT
Midodrine is an orally active adrenergic agonist useful in the treatment of hypotension. We have investigated the pharmacodynamics of its active metabolite after oral midodrine therapy in nine patients with severe orthostatic hypotension. Peak plasma levels of the metabolite were reached in 60 to 90 minutes and ranged from 25 to 56 ng/ml. The mean values for distribution volume, plasma clearance, and t1/2 were 4.0 L/kg, 23 ml/min/kg, and 2.1 hours, respectively. Heart rate increased after 5 to 10 mg doses and the increases were statistically significant (P less than 0.05) at 120 minutes. An apparent increase in blood pressure was not statistically significant. The patients said that they felt better.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Etanolaminas
/
Hipotensão Ortostática
/
Midodrina
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
1986
Tipo de documento:
Article