Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma.

Razumilava, Nataliya; Gradilone, Sergio A; Smoot, Rory L; Mertens, Joachim C; Bronk, Steven F; Sirica, Alphonse E; Gores, Gregory J

Razumilava, Nataliya; Gradilone, Sergio A; Smoot, Rory L; Mertens, Joachim C; Bronk, Steven F; Sirica, Alphonse E; Gores, Gregory J.

Afiliação

Razumilava N; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Gradilone SA; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Smoot RL; Department of General Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Mertens JC; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Division of Gastroenterology and Hepatology, University Hospital Zurich, Switzerland.
Bronk SF; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Sirica AE; Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Gores GJ; Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: gores.gregory@mayo.edu.

J Hepatol ; 60(3): 599-605, 2014 Mar.

Article em En | MEDLINE | ID: mdl-24239776

Assuntos

Neoplasias dos Ductos Biliares/patologia; Ductos Biliares Intra-Hepáticos; Quimiotaxia; Colangiocarcinoma/patologia; Proteínas Hedgehog/fisiologia; Transdução de Sinais/fisiologia; Linhagem Celular Tumoral; Cílios/fisiologia; Humanos; Metástase Neoplásica

Palavras-chave

4'-6-diamidino-2-phenylindole; Biliary tract cancer; CAFs; CCA; DAPI; Dominant-negative Ptch1; FBS; G-protein coupled receptor; Gli; Hedgehog; Hh; PBS; PTX; Patched-1; Ptch1; Shh; Smo; Smoothened; Sonic Hh; cancer-associated fibroblasts; cholangiocarcinoma; fetal bovine serum; glioma-associated transcriptional factor; pertussis toxin; phosphate-buffered saline; qRT-PCR; quantitative reverse transcription polymerase chain reaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Ductos Biliares / Ductos Biliares Intra-Hepáticos / Transdução de Sinais / Quimiotaxia / Colangiocarcinoma / Proteínas Hedgehog Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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