Safety of intranasal fentanyl in the out-of-hospital setting: a prospective observational study.
Ann Emerg Med
; 63(6): 699-703, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24268523
ABSTRACT
STUDY OBJECTIVE:
Initial out-of-hospital analgesia is sometimes hampered by difficulties in achieving intravenous access or lack of skills in administering intravenous opioids. We study the safety profile and apparent analgesic effect of intranasal fentanyl in the out-of-hospital setting.METHODS:
In this prospective observational study, we administered intranasal fentanyl in the out-of-hospital setting to adults and children older than 8 years with severe pain resulting from orthopedic conditions, abdominal pain, or acute coronary syndrome refractory to nitroglycerin spray. Patients received 1 to 3 doses of either 50 or 100 µg, and the ambulance crew recorded adverse effects and numeric rating scale (0 to 10) pain scores before and after treatment.RESULTS:
Our 903 evaluable patients received a mean cumulative fentanyl dose of 114 µg (range 50 to 300 µg). There were no serious adverse effects and no use of naloxone. Thirty-six patients (4%) experienced mild adverse effects mild hypotension, nausea, vomiting, vertigo, abdominal pain, rash, or decrease of Glasgow Coma Scale score to 14. The median reduction in pain score was 3 (interquartile range 2 to 5) after fentanyl administration.CONCLUSION:
The out-of-hospital administration of intranasal fentanyl in doses of 50 to 100 µg is safe and appears effective.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fentanila
/
Analgésicos Opioides
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Adult
/
Aged
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Aged80
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Child
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Emerg Med
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Dinamarca