Reprogramming homing endonuclease specificity through computational design and directed evolution.

Thyme, Summer B; Boissel, Sandrine J S; Arshiya Quadri, S; Nolan, Tony; Baker, Dean A; Park, Rachel U; Kusak, Lara; Ashworth, Justin; Baker, David

Thyme, Summer B; Boissel, Sandrine J S; Arshiya Quadri, S; Nolan, Tony; Baker, Dean A; Park, Rachel U; Kusak, Lara; Ashworth, Justin; Baker, David.

Afiliação

Thyme SB; Department of Biochemistry, University of Washington, UW Box 357350, 1705 NE Pacific St., Seattle, WA 98195, USA, Graduate Program in Biomolecular Structure and Design, University of Washington, UW Box 357350, 1705 NE Pacific St., Seattle, WA 98195, USA, Graduate Program in Molecular and Cellular Biology, University of Washington, UW Box 357275, 1959 NE Pacific St., Seattle, WA 98195, USA, Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, Imperial College Road

Nucleic Acids Res ; 42(4): 2564-76, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24270794

Assuntos

Evolução Molecular Direcionada/métodos; Endodesoxirribonucleases/química; Endodesoxirribonucleases/metabolismo; Engenharia de Proteínas/métodos; Animais; Anopheles/genética; Bactérias/genética; Biologia Computacional; Clivagem do DNA; Endodesoxirribonucleases/genética; Genes de Insetos; Modelos Moleculares; Especificidade por Substrato

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Engenharia de Proteínas / Evolução Molecular Direcionada / Endodesoxirribonucleases Limite: Animals Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2014 Tipo de documento: Article

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