Long non-coding RNAs: new players in cell differentiation and development.
Nat Rev Genet
; 15(1): 7-21, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24296535
ABSTRACT
Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
/
Mecanismo Genético de Compensação de Dose
/
Impressão Genômica
/
Regulação da Expressão Gênica no Desenvolvimento
/
Organogênese
/
RNA Longo não Codificante
/
Mamíferos
/
Modelos Genéticos
Limite:
Animals
Idioma:
En
Revista:
Nat Rev Genet
Assunto da revista:
GENETICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Itália