Carborane-based carbonic anhydrase inhibitors.
Angew Chem Int Ed Engl
; 52(51): 13760-3, 2013 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-24307504
ABSTRACT
CA inhibitors Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozymeâ
IX. Crystal structures of the carboranes in the active site provide information that can be applied to the structure-based design of specific inhibitors.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Anidrase Carbônica
Limite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2013
Tipo de documento:
Article