[Observational and cross-sectional study of prevalence and severity of the opioid-induced bowel dysfunction]. / Prevalencia y severidad de la disfunción intestinal inducida por opioides.
Aten Primaria
; 46(1): 32-9, 2014 Jan.
Article
em Es
| MEDLINE
| ID: mdl-24332445
ABSTRACT
OBJECTIVE:
To analyze the prevalence and severity of the opioid-induced bowel dysfunction (OBD) symptoms.DESIGN:
Epidemiological, observational and cross-sectional study. LOCATION Six Spanish centers participated.PARTICIPANTS:
A total of 317 outpatients with a diagnosis of cancer pain or non-cancer pain treated with a unique opioid were recruited. MAIN MEASUREMENTS The prevalence of OBD symptoms was measured using a visual analog scale (VAS 0-100), and constipation was also assessed by the Bowel Function Index (BFI). The treatment for gastrointestinal symptoms was recorded, and the frequency of symptoms between different opioid treatments was compared. Finally, quality of life was evaluated.RESULTS:
The prevalence of OBD with at least one gastrointestinal disorder was 94.6%, with constipation being the most frequent symptom (BFI 91.6%; VAS 90.2%) and nearly half of the patients showed three or more symptoms with a VAS ≥ 4. No significant differences were detected in the prevalence of symptoms between the opioid groups. A decrease in the wellbeing of patients was detected related to moderate to severe gastrointestinal symptoms.CONCLUSIONS:
A high rate of gastrointestinal disorders probably related to OBD have been confirmed in patients on opioid therapy, highlighting the need for new drug strategies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Crônica
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Gastroenteropatias
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Analgésicos Opioides
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
Es
Revista:
Aten Primaria
Ano de publicação:
2014
Tipo de documento:
Article