A sensitive HPLC-MS/MS method for the determination of dolutegravir in human plasma.

Bennetto-Hood, Chantelle; Tabolt, Glenn; Savina, Paul; Acosta, Edward P

Bennetto-Hood, Chantelle; Tabolt, Glenn; Savina, Paul; Acosta, Edward P.

Afiliação

Bennetto-Hood C; Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States.
Tabolt G; Bioanalytical Science and Toxicokinetics, PTS DMPK, GlaxoSmithKline, Research Triangle Park, NC, United States.
Savina P; Biotransformation and Drug Disposition, PTS DMPK, GlaxoSmithKline, Research Triangle Park, NC, United States.
Acosta EP; Division of Clinical Pharmacology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States. Electronic address: eacosta@uab.edu.

J Chromatogr B Analyt Technol Biomed Life Sci ; 945-946: 225-32, 2014 Jan 15.

Article em En | MEDLINE | ID: mdl-24361860

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Inibidores de Integrase de HIV/sangue; Compostos Heterocíclicos com 3 Anéis/sangue; Espectrometria de Massas em Tandem/métodos; Calibragem; Humanos; Limite de Detecção; Oxazinas; Piperazinas; Piridonas

Palavras-chave

ARVs; AUC; AcN; CV; DMSO; DTG; Dolutegravir; EDTA; EFV; EVG; HIV; Human; INSTI; IPA; IS; Integrase inhibitor; LCMS/MS; LLOQ; MRM; Mass spectrometry; MeOH; NRTI; PK; QC; RAL; UDP-glucuronosyl transferase 1A1; UGT1A1; ULQ; acetonitrile; antiretrovirals; area under the concentrationtime curve; coefficient of variation; dimethyl sulfoxide; dolutegravir; efavirenz; elvitegravir; ethylenediamine tetraacetic acid; human immunodeficiency virus; integrase strand transfer inhibitor; internal standard; isopropanol; liquid chromatography tandem mass spectrometry; lower limit of quantitation; methanol; multi reaction monitoring; nucleoside reverse transcriptase inhibitor; pharmacokinetic; quality control; raltegravir; upper limit of quantitation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida de Alta Pressão / Inibidores de Integrase de HIV / Espectrometria de Massas em Tandem / Compostos Heterocíclicos com 3 Anéis Tipo de estudo: Clinical_trials / Diagnostic_studies / Guideline Limite: Humans Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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