A phase 1 study of prasugrel in patients with sickle cell disease: effects on biomarkers of platelet activation and coagulation.

Jakubowski, Joseph A; Zhou, Chunmei; Jurcevic, Stipo; Winters, Kenneth J; Lachno, D Richard; Frelinger, Andrew L; Gupta, Neehar; Howard, Jo; Payne, Christopher D; Mant, Timothy G

Jakubowski, Joseph A; Zhou, Chunmei; Jurcevic, Stipo; Winters, Kenneth J; Lachno, D Richard; Frelinger, Andrew L; Gupta, Neehar; Howard, Jo; Payne, Christopher D; Mant, Timothy G.

Afiliação

Jakubowski JA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN USA. Electronic address: joseph@lilly.com.
Zhou C; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN USA.
Jurcevic S; King's College, London UK.
Winters KJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN USA.
Lachno DR; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK.
Frelinger AL; Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, MA USA.
Gupta N; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN USA.
Howard J; Guy's and St. Thomas' Hospital, London UK.
Payne CD; Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK.
Mant TG; Quintiles Drug Research Unit at Guy's Hospital, London UK.

Thromb Res ; 133(2): 190-5, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24368019

Assuntos

Anemia Falciforme/tratamento farmacológico; Coagulação Sanguínea/efeitos dos fármacos; Plaquetas/efeitos dos fármacos; Piperazinas/uso terapêutico; Ativação Plaquetária/efeitos dos fármacos; Antagonistas do Receptor Purinérgico P2Y/uso terapêutico; Tiofenos/uso terapêutico; Difosfato de Adenosina/metabolismo; Adulto; Anemia Falciforme/metabolismo; Biomarcadores/metabolismo; Plaquetas/metabolismo; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Cloridrato de Prasugrel; Adulto Jovem

Palavras-chave

ADP; Biomarkers; CD40 ligand; CD40L; EDTA; GPIIbIIIa; P2Y(12) receptor antagonist; PD; PK; Platelets; Prasugrel; RBCs; SCD; SD; Sickle cell disease; TF; TXB(2); VOC; adenosine diphosphate; ethylenediaminetetraacetic acid; glycoprotein IIb-IIIa; pharmacodynamics; pharmacokinetics; red blood cells; sickle cell disease; standard deviation; thromboxane B(2); tissue factor; vaso-occlusive crisis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Tiofenos / Coagulação Sanguínea / Plaquetas / Ativação Plaquetária / Antagonistas do Receptor Purinérgico P2Y / Anemia Falciforme Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Thromb Res Ano de publicação: 2014 Tipo de documento: Article

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