Lectin coated MgO nanoparticle: its toxicity, antileishmanial activity, and macrophage activation.
Drug Chem Toxicol
; 37(4): 400-9, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24393043
ABSTRACT
The purpose of this research was to evaluate toxicity of uncoated magnesium oxide nanoparticles (MgO NPs), MgO NPs coated with Peanut agglutinin (PNA) lectin, and PNA alone on the promastigotes of Leishmania major (L. major) and macrophages of BALB/c mice. On the other hand, antileishmanial property of uncoated MgO NPs, lectin coated MgO NPs, and PNA lectin alone was evaluated, and also macrophage activation was investigated after treatment with these materials by measurement of nitrite, H2O2, and some interleukins. This study showed that PNA lectin and lectin coated MgO NPs had approximately no toxicity on L. major and macrophages, but some toxic effects were observed for uncoated MgO NPs, especially at concentration of 500 µg/mL. Interestingly, lectin coated MgO NPs had the highest antileishmanial activity and macrophage activation, compared with uncoated MgO NPs and PNA lectin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aglutinina de Amendoim
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Nanopartículas
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Óxido de Magnésio
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Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Drug Chem Toxicol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Irã