Use of time attenuation curves to determine steady-state characteristics before C-arm CT measurement of cerebral blood volume.
Neuroradiology
; 56(3): 245-9, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24449134
ABSTRACT
INTRODUCTION:
Cerebral blood volume (CBV) measurement by flat panel detector CT (FPCT) in the angiography suite seems to be a promising tool for patient management during endovascular therapies. A steady state of contrast agent distribution is mandatory during acquisition for accurate FPCT CBV assessment. To the best of our knowledge, this was the first time that steady-state parameters were studied in clinical practice.METHODS:
Before the CBV study, test injections were performed and analyzed to determine a customized acquisition delay from injection for each patient. Injection protocol consisted in the administration of 72 mL of contrast agent material at the injection rate of 4.0 mL/s followed by a saline flush bolus at the same injection rate. Peripheral or central venous accesses were used depending on their availability. Twenty-four patients were treated for different types of neurovascular diseases. Maximal attenuation, steady-state length, and steady-state delay from injection were derived from the test injections' time attenuation curves.RESULTS:
With a 15 % threshold from maximum attenuation values, average steady-state duration was less than 10 s. Maximum average steady-state duration with minimal delay variation was obtained with central injection protocols.CONCLUSION:
With clinically acceptable contrast agent volumes, steady state is a brief condition; thus, fast rotation speed acquisitions are needed. The use of central injections decreases the variability of steady-state's delay from injection. Further studies are needed to optimize and standardize injection protocols to allow a larger diffusion of the FPCT CBV measurement during endovascular treatments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Tri-Iodobenzoicos
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Determinação do Volume Sanguíneo
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Encéfalo
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Angiografia Cerebral
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Tomografia Computadorizada por Raios X
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Modelos Cardiovasculares
Tipo de estudo:
Diagnostic_studies
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Guideline
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Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neuroradiology
Ano de publicação:
2014
Tipo de documento:
Article